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Diabetes is among the most frequently reported comorbidities in patients with coronavirus disease 2019 (COVID-19) and it represents a strong risk factor for developing severe, critical and fatal forms of COVID-19. The association between diabetes and worse outcome in viral infections is not unexpected, as hyperglycemia is detrimental to the control of viremia and inflammation, and very often linked to accelerated morbidity and mortality in a majority of patients. Understanding the pathophysiological mechanisms underlying the impact of diabetes on COVID-19 progression is now under critical scrutiny in several ongoing investigations, with the ultimate aim of maximizing therapeutic outcomes. On the other hand, there is a new school of thought that COVOD-19 and its devastating ravage on multiple organs could be causally linked to new-onset diabetes. Thus, the threatening new lesson is that there might be a bidirectional relationship between COVID-19 and diabetes. This review is unique in that it summarizes the very recent literature that supports why we should revisit studying virus-induced diabetes in the context of COVID-19.

Does COVID-19 Warn Us to Revisit Virus-Induced Diabetes?