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During sperm maturation, chromatin undergoes an extensive compaction through the progressive replacement of histones with basic, positively-charged proteins called protamines. Interestingly, in human and other vertebrates, 5–15% of the paternal genome retains a somatic-like structure. It has been suggested that preserved nucleosomes have a role in promoting transcription after fertilization, however their localization and function is still a matter of debate. The aim of the present work was to understand if the localization of histones in human sperm DNA is affected by genome composition, a feature linked to several biological functions. In order to do that, we mapped histone-enriched sequences along isochores, which are large chromosomal territories characterized by fairly homogeneous guanine and cytosine (GC) composition.

Distribution of Nucleosome-enriched Sequences of Human Sperm Chromatin Along Isochores