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Selective accumulation of B-10 compound in tumour tissue is a fundamentalcondition for the achievement of BNCT (Boron Neutron Capture Therapy), sincethe effectiveness of therapy irradiation derives just from neutron capturereaction of B-10. Hence, the determination of the B-10 concentration ratio,between tumour and healthy tissue, and a control of this ratio, during thetherapy, are essential to optimise the effectiveness of the BNCT, which it isknown to be based on the selective uptake of B-10 compound. In this work,experimental methods are proposed and evaluated for the determination in vivoof B-10 compound in biological samples, in particular based on neutronradiography and gammaray spectroscopy by telescopic system. Measures and MonteCarlo calculations have been performed to investigate the possibility ofexecuting imaging of the 10B distribution, both by radiography with thermalneutrons, using 6LiF/ZnS:Ag scintillator screen and a CCD camera, and byspectroscopy, based on the revelation of gamma-ray reaction products from B-10and the H. A rebuilding algorithm has been implemented. The present study hasbeen done for the standard case of B-10 uptake, as well as for proposed case inwhich, to the same carrier, is also synthesized Gd-157, in the amount of isused like a contrast agent in NMRI.

A suggestion for ¹­º B imaging during boron neutron capture therapy

A suggestion for ¹º B imaging during boron neutron capture therapy