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In 1529 the painter Antonio de Holanda made several paintngs in Toledo for the Emperor Charles V and his wife Isabella of Portugal, including a portrait of the Empress with her heir, Prince Philip, in arms, in the guise of the Virgin and Child. This paper presents a painting that could be the closest version of the original portrait, that is considered lost.

La emperatriz Isabel de Portugal con el príncipe Felipe en brazos (1529): en busca de un retrato perdido de António de Holanda