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This paper proposes a method for fabricating gadolinium diethylenetriamine pentaacetic acid-immobilized silica particles (SiO2/Gd–DTPA). Preparation of a colloid solution of spherical silica particles with an average size of 101.7±11.7 nm was performed by a sol-gel method at 35◦C using 0.2 M tetraethylorthosilicate, 25 M H2O and 0.01 M NaOH in ethanol. Amino groups were introduced on the silica particles with 6 × 10−3 M (3aminopropyl)triethoxysilane (APES) at 35◦C (SiO2–NH2), which resulted in their average particle of 80.5±9.7 nm. Gd–DTPA was immobilized on the SiO2–NH2 particle surface with 5 × 10−4 M Gd–DTPA in 50/50 (v/v) water/dimethylformamide solution at 35◦C , which provided their average particle of 101.6±12.3 nm. The APESintroduction and the Gd–DTPA-immobilization did not change the spherical structure, and shifted an iso-electric point of particles to higher pH for the APES-introduction and then to lower pH for the Gd–DTPA-immobilization, which indicated that APES and Gd–DTPA were successfully attached on the particle surface with no chemical damage. A relaxivity value for T1-weighted imaging of the SiO2/Gd–DTPA particle colloid solution was 2.7 mM −1 s−1, that was 64% of that for Magnevist. [DOI: 10.1380/ejssnt.2015.42]

Direct Immobilization of Gadolinium Complex on Silica Particles and Their MRI Properties