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Does cannabis represent society's next major misstep in its unending quest to relieve suffering from persistent pain? Perhaps. But instead, imagine if science could harness medical cannabis, with its myriad of biologically active compounds, to produce chemotypes tailored to the physical and mental presentation of each pain patient. By doing so, could this “simple” plant embody the leading edge of precision pain medicine to produce maximal benefit with minimal risk? This notion may be hard to conceptualize at present, although many clinicians might have thought it equally unimaginable, if asked a decade ago, to ever envisage a peer-reviewed editorial such as this one discussing the medicinal merits of cannabis. To be clear, the journey over the next decade or more to exploit the impact of medicinal cannabis as an analgesic will be challenging. Its success, or failure, will be determined by the willingness to reconsider several currently well-established tenets of pain and cannabis. These shifts in perspective include acknowledging the significance of, initially phenotypic and ultimately genotypic, interindividual variability within pain; recognizing that our understanding of cannabis and the endocannabinoid system is still in its infancy; and utilizing methodologies beyond traditional scientific inquiry to elucidate the putative benefits and risks of cannabis. In short, it will take a readiness to rethink, …

Medical Cannabis and Pain Management: How Might the Role of Cannabis Be Defined in Pain Medicine?