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In this issue of Clinical Chemistry , a group led by Miao He at Emory University describes a new method for the qualitative profiling of free oligosaccharides and other glycoaminoacids in urine samples (1). The analytical platform is MALDI-TOF mass spectrometry, a technology that is making a rapid transition from an elite proteomics research tool to a diagnostic tool broadly adopted in laboratory medicine, particularly in clinical microbiology (2). The authors have successfully targeted 11 different lysosomal disorders that have very similar clinical presentations and are virtually indistinguishable in the first few months of life, when a diagnostic evaluation is likely to take place. Notably, the authors have provided a clear and objective road map to the interpretation of abnormal profiles. Table 1 of this report is a truly fundamental contribution that should pave the way to rapid implementation of this method as well as objective and consistent interpretation of clinical results. This outcome has been hardly the case for the last 4 decades. Indeed, the significance of this report cannot be fully appreciated by …

From Art to Science: Oligosaccharide Analysis by MALDI-TOF Mass Spectrometry Finally Replaces 1-Dimensional Thin-Layer Chromatography