Open AccessCirculating Fetal Cell-Free DNA Fractions Differ in Autosomal Aneuploidies and Monosomy X
Author(s) -
Richard P. Rava,
Anupama Srinivasan,
Amy J. Sehnert,
Diana W. Bianchi
Publication year - 2013
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2013.207951
Subject(s) - monosomy , cell free fetal dna , aneuploidy , fetus , trisomy , prenatal diagnosis , biology , genetics , microbiology and biotechnology , karyotype , chromosome , pregnancy , gene
Noninvasive prenatal testing based on massively parallel sequencing (MPS) of cell-free DNA in maternal plasma has become rapidly integrated into clinical practice for detecting fetal chromosomal aneuploidy. We directly determined the fetal fraction (FF) from results obtained with MPS tag counting and examined the relationships of FF to such biological parameters as fetal karyotype and maternal demographics.
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