Open AccessHigh-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing
Author(s) -
Stephanie C Y Yu,
Lee Sw,
Peiyong Jiang,
Tak Yeung Leung,
K.C. Allen Chan,
Rossa W. K. Chiu,
YM Dennis Lo
Publication year - 2013
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2013.203679
Subject(s) - fetus , dna , massive parallel sequencing , cell free fetal dna , dna sequencing , biology , andrology , chemistry , medicine , pregnancy , prenatal diagnosis , genetics
With the advent of massively parallel sequencing (MPS), DNA analysis can now be performed in a genomewide manner. Recent studies have demonstrated the high precision of MPS for quantifying fetal DNA in maternal plasma. In addition, paired-end sequencing can be used to determine the size of each sequenced DNA fragment. We applied MPS in a high-resolution investigation of the clearance profile of circulating fetal DNA.
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