Open AccessSandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery Disease
Author(s) -
Boris Bigalke,
Oliver Pötz,
Elisabeth Kremmer,
Tobias Geisler,
Peter Seizer,
Valentina O. Püntmann,
Alkystis Phinikaridou,
Amedeo Chiribiri,
Eike Nagel,
René M. Botnar,
Thomas Joos,
Meinrad Gawaz
Publication year - 2011
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2010.158527
Subject(s) - immunoassay , medicine , myocardial infarction , coronary artery disease , acute coronary syndrome , unstable angina , gastroenterology , platelet , area under the curve , platelet membrane glycoprotein , subgroup analysis , cardiology , gpvi , antibody , immunology , confidence interval
Platelet glycoprotein VI (pGPVI) expression is increased in acute coronary syndrome (ACS), reflecting platelet activation. There is no reliable method available to measure pGPVI. Our aim was to develop a bead-based sandwich immunoassay to measure soluble GPVI (sGPVI).
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