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Featured Article: Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 2002;359:572–7.2This report in The Lancet generated a great deal of excitement about the application of mass spectrometry (MS) to discover candidate protein biomarkers for early-stage ovarian cancer. MS-based serum/plasma biomarker profiling was launched in a flourish of optimism to meet the urgent need for biomarkers of early-stage cancer, a need that still exists today. Before 1998, very few investigators used MS (MALDI-TOF or electrospray ionization) to directly analyze blood, because serum was considered too complex and “dirty” for direct introduction into expensive and sophisticated MS research instruments. The door was opened to the use of MS for biomarker research in 1998 with SELDI, a new modification of MALDI-TOF technology. Researchers were immediately intrigued by the SELDI-TOF approach because body fluids could be applied directly to the chip surface and then analyzed to generate an ion fingerprint (1, 2). SELDI had relatively low resolution and could not …

Mass Spectrometry–Based Protein Biomarker Discovery: Solving the Remaining Challenges to Reach the Promise of Clinical Benefit