Open AccessFully Traceable Absolute Protein Quantification of Somatropin That Allows Independent Comparison of Somatropin Standards
Author(s) -
Caroline Pritchard,
Milena Quaglia,
Chris Mussell,
William Burkitt,
Helen Parkes,
Gavin O’Connor
Publication year - 2009
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2009.124354
Subject(s) - traceability , somatropin , chemistry , isotope dilution , chromatography , human growth hormone , isobaric process , kilogram , measurement uncertainty , mass spectrometry , growth hormone , mathematics , biochemistry , statistics , medicine , body weight , physics , hormone , thermodynamics
Measurement traceability in clinical chemistry is required to standardize clinical results irrespective of the measurement procedure and laboratory. The traceability of many protein substances is maintained by reference to the first standard produced, which may no longer exist, with values assigned by consensus. Independent methods that provide traceability to the Système d'Unité International for all relevant properties of a protein standard could remove reliance on the original standard preparations.
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