Open AccessActivity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement
Author(s) -
Duncan J. Campbell,
Juerg Nussberger,
Michael Stowasser,
A.H. Jan Danser,
Alberto Morganti,
Erik Frandsen,
Joël Ménard
Publication year - 2009
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2008.118000
Subject(s) - renin–angiotensin system , plasma renin activity , immunoassay , renin inhibitor , chemistry , pharmacology , medicine , immunology , antibody , blood pressure
Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the plasma renin activity (PRA) assay and the renin immunoassay. The clinical application of renin inhibitor therapy has thrown into focus the differences in information provided by activity assays and immunoassays for renin and prorenin measurement and has drawn attention to the need for precautions to ensure their accurate measurement.
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