Open AccessUltrasensitive Flow-based Immunoassays Using Single-Molecule Counting
Author(s) -
John A. Todd,
Bob Freese,
Ann Lu,
D. Held,
Jennifer R. Morey,
Richard Livingston,
Philippe Goix
Publication year - 2007
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2007.091181
Subject(s) - immunoassay , chromatography , detection limit , troponin i , medicine , chemistry , immunology , antibody , myocardial infarction
Immunoassay (IA) technology has expanded the clinical utility of protein biomarkers, but demands for increased sensitivity, dynamic reporting ranges, and small sample volumes have limited the potential clinical usefulness of many biomarkers. We assessed the performance, including limits of detection (LODs) and the dynamic reporting range, of an IA-based technology, Erenna Immunoassay System, for a series of biomarkers, including cardiac troponin I (cTnI).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom