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Li et al. (1) should be congratulated for a valiant effort to validate 3 previously identified serum breast cancer biomarkers by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS).Because there is considerable controversy on the value of this technology for cancer diagnostics (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), it is important to comment on validation studies aiming to reproduce previously published data. Among 3 previously reported biomarkers, BC1, BC2, and BC3, one …

Validation of Breast Cancer Biomarkers Identified by Mass Spectrometry