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The hemochromatosis (HFE) gene encodes the HFE protein, a transmembrane glycoprotein that is implicated in the modulation of iron uptake from the diet (1). The C282Y mutation in this gene is known to be associated with moderately increased serum iron indices. Recently, several studies have described an association between increased maternal iron status and an unfavorable pregnancy outcome (2)(3). Preeclampsia is one of the most common pregnancy-related syndromes as well as a major cause of fetal and maternal morbidity and mortality. Preeclampsia is defined by de novo hypertension and proteinuria in pregnancy. The etiology of preeclampsia is complex and not fully understood, but abnormal placentation and …

Preeclampsia and the C282Y Mutation in the Hemochromatosis (HFE) Gene