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Respiratory syncytial virus (RSV) is the major cause of respiratory disease in infants and young children; it is also a significant problem in the elderly [1, 2]. RSV is a nonsegmented, negative strand RNA virus (nsNSV). Like other viruses in this group, the genome is a template for two distinct processes: transcription, which yields capped and polyadenylated mRNAs, and replication, which yields an encapsidated antigenome RNA. The antigenome, in turn, acts as a template for genome synthesis (Fig 1A; [3]). RSV encodes its own RNA-dependent RNA polymerase, which is responsible for both transcription and replication. This presents an intriguing puzzle, namely, how does the RSV polymerase perform both activities from the same template?

Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication