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Cancers emerge after the immune system fails to control and contain tumors. Multiple tumorspecific mechanisms create tumor environments where the immune system is forced to tolerate tumors and their cells instead of eliminating them. The goal of cancer immunotherapy is to rescue the immune system’s natural ability to eliminate tumors [1]. Here, we uncork the unique biology of the bottle-shaped protozoan Toxoplasma gondii. We reveal how this microbe when engineered into a safe nonreplicating vaccine effectively breaks tumor control over the immune system, which then unleashes potent immunity against already established cancer, thereby promoting survival and preventing cancer recurrence.

Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii