English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Gamma-herpesvirus infections are regulated by both CD4 +  and CD8 +  T cells. However clinical disease occurs mainly in CD4 +  T cell-deficient hosts. In CD4 +  T cell-deficient mice, CD8 +  T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8 +  T cells controlled epithelial infection, but CD4 +  T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8 +  T cells to prevent disease. Thus, viral CD8 +  T cell evasion led to niche-specific immune control, and an essential role for CD4 +  T cells in limiting chronic infection.

CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection