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The  Toxoplasma gondii  genome contains two aromatic amino acid hydroxylase genes,  AAH1  and  AAH2  encode proteins that produce L-DOPA, which can serve as a precursor of catecholamine neurotransmitters. It has been suggested that this pathway elevates host dopamine levels thus making infected rodents less fearful of their definitive Felidae hosts. However, L-DOPA is also a structural precursor of melanins, secondary quinones, and dityrosine protein crosslinks, which are produced by many species. For example, dityrosine crosslinks are abundant in the oocyst walls of  Eimeria  and  T .  gondii , although their structural role has not been demonstrated, Here, we investigated the biology of  AAH  knockout parasites in the sexual reproductive cycle within cats. We found that ablation of the  AAH  genes resulted in reduced infection in the cat, lower oocyst yields, and decreased rates of sporulation. Our findings suggest that the  AAH  genes play a predominant role during infection in the gut of the definitive feline host.

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat