English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Although it is generally believed that CD4 +  T cells play important roles in anti- Leishmania  immunity, some studies suggest that they may be dispensable, and that MHC II-restricted CD3 + CD4 − CD8 −  (double negative, DN) T cells may be more important in regulating primary anti- Leishmania  immunity. In addition, while there are reports of increased numbers of DN T cells in  Leishmania -infected patients, dogs and mice, concrete evidence implicating these cells in secondary anti- Leishmania  immunity has not yet been documented. Here, we report that DN T cells extensively proliferate and produce effector cytokines (IFN-γ, TNF and IL-17) and granzyme B (GrzB) in the draining lymph nodes and spleens of mice following primary and secondary  L. major  infections. DN T cells from healed mice display functional characteristics of protective anti- Leishmania  memory-like cells: rapid and extensive proliferation and effector cytokines production following  L. major  challenge  in vitro  and  in vivo . DN T cells express predominantly (> 95%) alpha-beta T cell receptor (αβ TCR), are  Leishmania -specific, restricted mostly by MHC class II molecules and display transcriptional profile of innate-like genes. Using  in vivo  depletion and adoptive transfer studies, we show that DN T cells contribute to optimal primary and secondary anti- Leishmania  immunity in mice. These results directly identify DN T cells as important players in effective and protective primary and secondary anti- L. major  immunity in experimental cutaneous leishmaniasis.

MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major