English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Understanding African Trypanosomiasis (AT) host-pathogen interaction is the key to an “anti-disease vaccine”, a novel strategy to control AT. Here we provide a better insight into this poorly described interaction by characterizing the activation of a panel of endothelial cells by bloodstream forms of four African trypanosome species, known to interact with host endothelium.  T. congolense ,  T. vivax , and  T. b. gambiense  activated the endothelial NF-κB pathway, but interestingly, not  T. b. brucei . The parasitic TS (trans-sialidases) mediated this NF-κB activation, remarkably  via  their lectin-like domain and induced production of pro-inflammatory molecules not only  in vitro  but also  in vivo , suggesting a considerable impact on pathogenesis. For the first time, TS activity was identified in  T. b. gambiense  BSF which distinguishes it from the subspecies  T. b. brucei.  The corresponding TS were characterized and shown to activate endothelial cells, suggesting that TS represent a common mediator of endothelium activation among trypanosome species with divergent physiopathologies.

Identification of Trans-Sialidases as a Common Mediator of Endothelial Cell Activation by African Trypanosomes