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Trypanosomatid parasites are notorious for the human diseases they cause throughout Africa and South America. However, non-pathogenic trypanosomatids are also found worldwide, infecting a wide range of hosts. One example is  Trypanosoma (Megatrypanum) theileri , a ubiquitous protozoan commensal of bovids, which is distributed globally. Exploiting knowledge of pathogenic trypanosomatids, we have developed  Trypanosoma theileri  as a novel vehicle to deliver vaccine antigens and other proteins to cattle. Conditions for the growth and transfection of  T. theileri  have been optimised and expressed heterologous proteins targeted for secretion or specific localisation at the cell interior or surface using trafficking signals from  Trypanosoma brucei . In cattle, the engineered vehicle could establish in the context of a pre-existing natural  T. theileri  population, was maintained long-term and generated specific immune responses to an expressed  Babesia  antigen at protective levels. Building on several decades of basic research into trypanosomatid pathogens,  Trypanosoma theileri  offers significant potential to target multiple infections, including major cattle-borne zoonoses such as  Escherichia coli ,  Salmonella  spp.,  Brucella abortus  and  Mycobacterium  spp. It also has the potential to deliver therapeutics to cattle, including the lytic factor that protects humans from cattle trypanosomiasis. This could alleviate poverty by protecting indigenous African cattle from African trypanosomiasis.

Targeting Cattle-Borne Zoonoses and Cattle Pathogens Using a Novel Trypanosomatid-Based Delivery System