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This study examined the antibacterial effect of protoporphyrin IX–ethylenediamine derivative (PPIX-ED)–mediated photodynamic antimicrobial chemotherapy (PPIX-ED-PACT) against  Pseudomonas aeruginosa in vitro  and  in vivo . PPIX-ED potently inhibited the growth of  Pseudomonas aeruginosa  by inducing reactive oxygen species production via photoactivation. Atomic force microscopy revealed that PPIX-ED-PACT induced the leakage of bacterial content by degrading the bacterial membrane and wall. As revealed using acridine orange/ethidium bromide staining, PPIX-ED-PACT altered the permeability of the bacterial membrane. In addition, the antibacterial effect of PPIX-ED-PACT was demonstrated in an  in vivo  model of  P .  aeruginosa -infected wounds. PPIX-ED (100 μM) decreased the number of  P .  aeruginosa  colony-forming units by 4.2 log 10 . Moreover, histological analysis illustrated that the wound healing rate was 98% on day 14 after treatment, which was 10% higher than that in the control group. According to the present findings, PPIX-ED-PACT can effectively inhibit the growth of  P .  aeruginosa in vitro  and  in vivo .

Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds