English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

KHM-1 was first reported in 1997 in Japan as a novel metallo-β-lactamase mediated by  Citrobacter freundii  carrying pKHM-1 plasmid. There have been few reports in the clinical field since then. A  bla  KHM-1 –positive  Enterobacter hormaechei  subsp.  hoffmannii  in  E .  cloacae  complex, isolate OIPH-N069 was isolated from an inpatient blood culture in 2016. The isolate was characterized by whole-genome sequencing, comparative analysis of the  bla  KHM-1  encoding plasmid, antimicrobial susceptibility tests, and bacterial conjugation. OIPH-N069 was classified into ST78 of  E .  cloacae  complex, and was multidrug resistant because of the presence of antimicrobial resistance genes in addition to  bla  KHM-1  on its chromosome and plasmids.  bla  KHM-1  was located on 136,816 bp of the IncA/C 2  plasmid pN069-1, which could be transferred to different bacterial species. The backbone structure, genetic arrangement of the class 1 integron cassette, and the  bla  KHM-1  gene located downstream of the IncA/C 2  antibiotic resistance island, ARI-A, in pN069-1 and pKHM-1 were identical. Horizontal gene transfer of the  bla  CTX-M-2 –IS Ecp1  resistance gene module only occurred with pN069-1. The study findings indicate not only the structural conservation of  bla  KHM-1  encoding plasmids over time and across species, but also the risk of the spread of  bla  KHM-1  encoding plasmids to other bacterial species and the accumulation of additional resistance genes.

Molecular characterization of blaKHM-1 encoding plasmid in an Enterobacter hormaechei subsp. hoffmannii isolate from blood culture