English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective  To investigate age-associated changes in airway microbiome composition and their relationships with lung function and arterial stiffness among genetically matched young and elderly pairs.    Methods  Twenty-four genetically linked family pairs comprised of younger (≤40 years) and older (≥60 years) healthy participants were recruited (Total  n  = 48). Lung function and arterial stiffness (carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx)) were assessed. Sputum samples were collected for targeted 16S rRNA gene amplicon sequencing and correlations between microbiome composition, lung function and arterial stiffness were investigated.    Results  Elderly participants exhibited reductions in lung function (FEV1 ( p< 0.001), FVC ( p <0.001) and percentage FEV1/FVC ( p  = 0.003)) and a 1.3–3.9-fold increase in arterial stiffness ( p< 0.001) relative to genetically related younger adults. Elderly adults had a higher relative abundance of Firmicutes ( p  = 0.035) and lower relative abundance of Proteobacteria ( p  = 0.014), including specific genera  Haemophilus  ( p  = 0.024) and  Lautropia  ( p  = 0.020) which were enriched in the younger adults. Alpha diversity was comparable between young and elderly pairs ( p >0.05) but was inversely associated with lung function (FEV1%Predicted and FVC %Predicted) in the young ( p  = 0.006 and  p  = 0.003) though not the elderly ( p  = 0.481 and  p  = 0.696). Conversely, alpha diversity was negatively associated with PWV in the elderly ( p  = 0.01) but not the young ( p  = 0.569). Specifically, phylum Firmicutes including the genus  Gemella  were correlated with lung function (FVC %Predicted) in the young group ( p  = 0.047 and  p  = 0.040), while Fusobacteria and  Leptotrichia  were associated with arterial stiffness (PWV) in the elderly (both  p  = 0.004).    Conclusion  Ageing is associated with increased Firmicutes and decreased Proteobacteria representation in the airway microbiome among a healthy Asian cohort. The diversity and composition of the airway microbiome is independently associated with lung function and arterial stiffness in the young and elderly groups respectively. This suggests differential microbial associations with these phenotypes at specific stages of life with potential prognostic implications.

Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner