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Erinacine A-enriched  Hericium erinaceus  mycelia is a well-established potential therapeutic agent for neurodegenerative disorders. However, the effect of erinacine A-enriched  H .  erinaceus  mycelia on promoting longevity remains unclear. This is the first study to investigate the effect of erinacine A-enriched  H .  erinaceus  mycelia on lifespan-prolonging activity in  Drosophila melanogaster  and senescence-accelerated P8 (SAMP8) mice. Two hundred  D .  melanogaster  and 80 SAMP8 mice of both sexes were randomly divided into four groups and were administered with either the standard, low-dose, mid-dose, or high-dose erinacine A-enriched  H .  erinaceus  mycelia. After treatment, the lifespan was measured in  D .  melanogaster , and the lifespan, food intake and oxidative damage were evaluated in SAMP8 mice. Results showed that supplementation with erinacine A-enriched  H .  erinaceus  mycelia extended the lifespan in both  D .  melanogaster  and SAMP8 by a maximum of 32% and 23%, respectively, compared to the untreated controls. Moreover, erinacine A-enriched  H .  erinaceus  mycelia decreased TBARS levels and induced the anti-oxidative enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase. Together, these findings suggest that erinacine A-enriched  H .  erinaceus  mycelia supplement could promote longevity, mediated partly through the induction of endogenous antioxidants enzymes.

Erinacine A-enriched Hericium erinaceus mycelia promotes longevity in Drosophila melanogaster and aged mice