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The present study was aimed to develop a liposomal formulation of thymoquinone (Lip-TQ) to treat  Candida albicans  infection in diabetic mice. Streptozotocin (STZ) was injected to induce hyperglycemia and on day 3 post STZ administration, mice were intravenously infected with  C .  albicans . Various doses (2, 5 and 10 mg/kg) of Free or Lip-TQ were administered in  C .  albicans  infected diabetic mice. The effect of Lip-TQ was also determined on the organ indices, liver and kidney function parameters. Lip-TQ at a dose of 10 mg/kg significantly reduced the level of the blood glucose and alleviated the systemic  C .  albicans  infection in diabetic mice.  C .  albicans  infected diabetic mice treated with Lip-TQ at a dose of 10 mg/kg showed the survival rate of 70% as compared to that of 20% in the group treated with free TQ. The treatment with Lip-TQ resulted in the recovery of the organ indices, liver inflammation, kidney functioning and pancreas regeneration in diabetic mice. Moreover, TQ formulations also showed the direct therapeutic effect against candidiasis in the untreated or metformin-treated diabetic mice. Therefore, the findings of the present study support the use of Lip-TQ in the treatment of candidiasis in the diabetic patients.

Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice