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Many pharmaceuticals have negative effects on biota when released into the environment. For example, recent work has shown that the commonly prescribed antidiabetic drug, metformin ( N , N -dimethylbiguanide), has endocrine disrupting effects on fish. However, effects of metformin on aquatic primary producers are poorly known. We exposed cultured isolates of a freshwater chlorophyte,  Chlorella vulgaris , to a range of metformin concentrations (0–767.9 mg L -1 ) to test the hypothesis that exposure negatively affects photosynthesis and growth. A cessation of growth, increase in non-photochemical quenching (NPQ, NPQ max ), and reduced electron transport rate (ETR) were observed 24 h after exposure to a metformin concentration of 767.8 mg L -1  (4.6 mM). By 48 h, photosynthetic efficiency of photosystem II (F v /F m ), α, the initial slope of the ETR-irradiance curve, and E k  (minimum irradiance required to saturate photosynthesis) were reduced. At a lower concentration (76.8 mg L -1 ), negative effects on photosynthesis (increase in NPQ, decrease in ETR) were delayed, occurring between 72 and 96 h. No negative effects on photosynthesis were observed at an exposure concentration of 1.5 mg L -1 . It is likely that metformin impairs photosynthesis either through downstream effects from inhibition of complex I of the electron transport chain or via activation of the enzyme, SnRK1 (sucrose non-fermenting-related kinase 1), which acts as a cellular energy regulator in plants and algae and is an ortholog of the mammalian target of metformin, AMPK (5' adenosine monophosphate-activated protein kinase).

Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris