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Association has been reported between ambient fine particulate matter (PM) and adverse outcomes of cerebrovascular events. However, it remains unclear that whether short-term exposure to PM relates to stroke and the lag of health effects. This triggers us to examine the relationship between PM and population stroke morbidity in Chengdu.    Methods  The daily average concentration of atmospheric pollutants and meteorological factors and daily morbidity of stroke in Chengdu (2013–2015) were collected. Based on time series analysis-generalized additive models (GAM), single-pollutant, two-pollutant and multi-pollutant model were established. The effects of atmospheric PM 2.5  (defined as PM less than 2.5μm in aerodynamic diameter), PMc(defined as PM less than 10μm and more than 2.5μm in aerodynamic diameter) and PM 10  (defined as PM less than 10μm in aerodynamic diameter) concentration on the daily mortality of stroke were analyzed, respectively.    Results  The three-year mean concentrations of PM 2.5 , PMc and PM 10  for air pollutants were 75.9, 43.9 and 119.7 μg/m 3 , respectively. PM 2.5  on the current day (lag0) and with a moving average of 0–1 days were significantly associated with the increasing risk of stroke morbidity, and PM 2.5  with a lag of 0–1 days had greater association, whereas for PMc and PM 10  there were no significant association observed. In our study, every 10μg/m 3  increase of PM 2.5  was associated with 0.69% percent change in stroke morbidity (95%CI: 0.01~1.38). For females, every 10μg/m 3  increase of PM 2.5  contributes to 0.80% percent change of onset. And for the group of age less than 65, we observed 0.78% higher risk every 10μg/m 3  increase of PM 2.5 .    Conclusions  These findings suggest that short-term exposure to PM 2.5  within 1 day is associated with the onset of stroke, and the younger people (age<65) and females are more sensitive than older people and males.

Ambient fine particulate pollution and daily morbidity of stroke in Chengdu, China