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Bariatric surgery and other therapeutic options for obese patients are often evaluated by the loss of weight, reduction of comorbidities or improved quality of life. However, little is currently known about potential therapy-related changes in the adipose tissue of obese patients. The aim of this study was therefore to quantify fat fraction (FF) and T1 relaxation time by magnetic resonance imaging (MRI) after Roux-en-Y gastric bypass surgery and compare the resulting values with the preoperative ones. Corresponding MRI data were available from 23 patients (16 females and 7 males) that had undergone MRI before (M0) and one month after (M1) bariatric surgery. Patients were 22–59 years old (mean age 44.3 years) and their BMI ranged from 35.7–54.6 kg/m 2  (mean BMI 44.6 kg/m 2 ) at M0. Total visceral AT volumes (V VAT-T , in L) were measured by semi-automatic segmentation of axial MRI images acquired between diaphragm and femoral heads. MRI FF and T1 relaxation times were measured in well-defined regions of visceral (VAT) and subcutaneous (SAT) adipose tissue using two custom-made analysis tools. Average BMI values were 45.4 kg/m 2  at time point M0 and 42.4 kg/m 2  at M1. Corresponding V VAT-T  values were 5.94 L and 5.33 L. Intraindividual differences in both BMI and V VAT-T  were highly significant (p<0.001). Average relaxation times T1 VAT  were 303.7 ms at M0 and 316.9 ms at M1 (p<0.001). Corresponding T1 SAT  times were 283.2 ms and 280.7 ms (p = 0.137). Similarly, FF VAT  differences (M0: 85.7%, M1: 83.4%) were significant (p <0.01) whereas FF SAT  differences (M0: 86.1, M1: 85.9%) were not significant (p = 0.517). In conclusion, bariatric surgery is apparently not only related to a significant reduction in common parameters of adipose tissue distribution, here BMI and total visceral fat volume, but also significant changes in T1 relaxation time and fat fraction of visceral adipose tissue. Such quantitative MRI measures may potentially serve as independent biomarkers for longitudinal and cross-sectional measurements in obese patients.

MRI assessment of changes in adipose tissue parameters after bariatric surgery