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In the current study, we examined the role of  Ezh2  as an epigenetic modifier for the enteric neural crest cell development through H3K27me3.  Ezh2  conditional null mice were viable up to birth, but died within the first hour of life. In addition to craniofacial defects,  Ezh2  conditional null mice displayed reduced number of ganglion cells in the enteric nervous system. RT-PCR and ChIP assays indicated aberrant up-regulation of  Zic1 ,  Pax3 , and  Sox10  and loss of H3K27me3 marks in the promoter regions of these genes in the myenteric plexus. Overall, these results suggest that  Ezh2  is an important epigenetic modifier for the enteric neural crest cell development through repression of  Zic1 ,  Pax3 , and  Sox10 .

Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice