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The essential oil of  Chamaecyparis obtusa  ( C .  obtusa ), which is used in soap, toothpaste, and aromatic agents, has been known to have anti-inflammatory properties. In this study, we investigated the effects of microencapsulated  C .  obtusa  essential oil on airborne fungus-induced dendritic cell (DC) activation and Th immune responses. We stimulated monocyte-derived DCs with  Alternaria  alternate and lipopolysaccharide (LPS). To determine the anti-inflammatory effects, we pre-treated DCs with various concentrations of microencapsulated  C .  obtusa  essential oil and collected the supernatants to measure interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and we determined the expression of cell surface molecules. The effects of the essential oil on CD4 +  T cells polarization was determine by culturing stimulated DCs and autologous CD4 +  T cells.  Alternaria  enhanced the production of IL-6 and TNF-α from DCs, and pretreating DCs with 0.001, 0.01, and 0.05% of the essential oil significantly inhibited their production. Increased CD80 and CD86 expression by  Alternaria  was significantly inhibited with 0.05% of the essential oil.  Alternaria -induced IL-5, IL-10, and interferon-gamma from CD4 +  T cells were significantly inhibited with  C .  obtusa  essential oil in a dose dependent manner.  C .  obtusa  influenced both  Alternaria - and LPS-induced Th1 and Th2 polarization of CD4 +  T cells. These results suggest a novel pharmacological use for  C .  obtusa  essential oil to treat inflammatory airway diseases.

Effect of microencapsulated essential oil form Chamaecyparis obtusa on monocyte-derived dendritic cell activation and CD4+ T cell polarization