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Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epidermal cell polarity and differentiation. However, its role in the dermis has not been evaluated. We found that  Loxl2  is dispensable for mouse dermal development, maturation and homeostasis, yet affects dermal stiffness. Neither loss of  Loxl2  nor increased  Loxl2  expression affected dermal architecture following treatment with the phorbol ester TPA. Furthermore,  Loxl2  expression did not alter the stroma of DMBA-TPA-induced tumours. We conclude that, although  Loxl2  is expressed in both dermis and epidermis, its function appears largely confined to the epidermis.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation