English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Necrotic enteritis is an economically important poultry disease caused by the bacterium  Clostridium perfringens . There are currently no necrotic enteritis vaccines commercially available for use in broiler birds, the most important target population.  Salmonella -vectored vaccines represent a convenient and effective option for controlling this disease. We used a single attenuated  Salmonella  vaccine strain, engineered to lyse within the host, to deliver up to three  C .  perfringens  antigens. Two of the antigens were toxoids, based on  C .  perfringens  α-toxin and NetB toxin. The third antigen was fructose-1,6-bisphosphate aldolase (Fba), a metabolic enzyme with an unknown role in virulence. Oral immunization with a single  Salmonella  vaccine strain producing either Fba, α-toxoid and NetB toxoid, or all three antigens, was immunogenic, inducing serum, cellular and mucosal responses against  Salmonella  and the vectored  C .  perfringens  antigens. All three vaccine strains were partially protective against virulent  C .  perfringens  challenge. The strains delivering Fba only or all three antigens provided the best protection. We also demonstrate that both toxins and Fba are present on the  C .  perfringens  cell surface. The presence of Fba on the cell surface suggests that Fba may function as an adhesin.

Salmonella-vectored vaccine delivering three Clostridium perfringens antigens protects poultry against necrotic enteritis