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Objective  To study the characterization of Fe 3 O 4 @Au-C225 composite targeted MNPs.    Methods  Fe 3 O 4 @Au-C225 was prepared by the absorption method. The immunosorbent assay was used to evaluate its absorption efficiency at C225 Fc. ZETA SIZER3000 laser particle size analyzer, ultraviolet photometer and its characteristics were analyzed by VSM. the targeting effect of Fe 3 O 4 @Au-C225 composite targeted MNPs on U251 cells  in vitro  were detected by 7.0 Tesla Micro-MR; and subcutaneous transplanted human glioma in nude mice were performed the targeting effect in vivo after tail vein injection of Fe 3 O 4 @Au-C225 composite targeted MNPs by MRI.    Results  The self-prepared Fe 3 O 4 @Au composite MNPs can adsorb C225 with high efficiency of adsorption so that Fe 3 O 4 @Au-C225 composite targeted MNPs were prepared successfully. Fe 3 O 4 @Au-C225 composite targeted MNPs favorably targeted human glioma cell line U251  in vitro ; Fe 3 O 4 @Au-C225 composite targeted MNPs have good targeting ability to xenografted glioma on nude mice  in vivo , and can be traced by MRI.    Conclusion  The Fe 3 O 4 @Au-C225 composite targeted MNPs have the potential to be used as a tracer for glioma  in vivo .

Preparation and characterization of Fe3O4@Au-C225 composite targeted nanoparticles for MRI of human glioma