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Bacterial infectious diseases produced by  Vibrio  are the main cause of economic losses in aquaculture. During recent years it has been shown that the expression of virulence genes in some  Vibrio  species is controlled by a population-density dependent gene-expression mechanism known as quorum sensing (QS), which is mediated by the diffusion of signal molecules such as  N -acylhomoserine lactones (AHLs). QS disruption, especially the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), is one of the novel therapeutic strategies for the treatment of bacterial infections. In this study, we present the detection of AHLs in 34 marine  Vibrionaceae  strains. Three aquaculture-related pathogenic  Vibrio  strains,  V .  mediterranei  VibC-Oc-097,  V .  owensii  VibC-Oc-106 and  V .  coralliilyticus  VibC-Oc-193 were selected for further studies based on their virulence and high production of AHLs. This is the first report where the signal molecules have been characterized in these emerging marine pathogens and correlated to the expression of virulence factors. Moreover, the results of AHL inactivation in the three selected strains have been confirmed  in vivo  against brine shrimps ( Artemia salina ) and Manila clams ( Venerupis philippinarum ). This research contributes to the development of future therapies based on AHL disruption, the most promising alternatives for fighting infectious diseases in aquaculture.

plos one

AHL-lactonase expression in three marine emerging pathogenic Vibrio spp. reduces virulence and mortality in brine shrimp (Artemia salina) and Manila clam (Venerupis philippinarum)