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The Mediator complex is at the core of transcriptional regulation and plays a central role in plant immunity. The MEDIATOR25 (MED25) subunit of  Arabidopsis thaliana  regulates jasmonate-dependent resistance to  Botrytis cinerea  through interacting with the basic helix-loop-helix (bHLH) transcription factor of jasmonate signaling, MYC2. Another Mediator subunit, MED8, acts independently or together with MED25 in plant immunity. However, unlike MED25, the underlying action mechanisms of MED8 in regulating  B .  cinerea  resistance are still unknown. Here, we demonstrated that MED8 regulated plant immunity to  B .  cinerea  through interacting with another bHLH transcription factor, FAMA, which was previously shown to control the final proliferation/differentiation switch during stomatal development. Our research demonstrates that FAMA is also an essential component of  B .  cinerea  resistance. The  fama  loss-of-function mutants ( fama-1  and  fama-2 ) increased susceptibility to  B .  cinerea  infection and reduced defense-gene expression. On the contrary, transgenic lines constitutively overexpressing  FAMA  showed opposite  B .  cinerea  responses compared with the  fama  loss-of-function mutants.  FAMA -overexpressed plants displayed enhanced resistance to  B .  cinerea  infection and increased expression levels of defensin genes following  B .  cinerea  treatment. Genetic analysis of MED8 and FAMA suggested that FAMA-regulated pathogen resistance was dependent on MED8. In addition, MED8 and FAMA were both associated with the G-box region in the promoter of  ORA59 . Our findings indicate that the MED8 subunit of the  A .  thaliana  Mediator regulates plant immunity to  B .  cinerea  through interacting with the transcription factor FAMA, which was discovered to be a key component in  B .  cinerea  resistance.

plos one

The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA