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The Type VI Secretion System (T6SS) is an important virulence system that exists in many bacterial pathogens, and has emerged as a potent mediator of pathogenicity in  Acinetobacter baumannii . In this study, we inactivated one of the T6SS components  vgrG  (valine–glycine repeat G) gene in  A .  baumannii  ATCC 19606 and constructed a complementation strain. BEAS-2b human alveolar epithelial cells was adopted to assess bacterial adhesion, and wild female BALB/c mice were used for  in vivo  experiments to assess the bacterial killing ability to host. Upon deletion of the  vgrG  gene, increased antimicrobial resistance to ampicillin/sulbactam, but reduced resistance to chloramphenicol were observed. The  vgrG  mutant strain showed lower growth rate, reduced eukaryotic cell adherence and impaired lethality in mice. However, the  vgrG  mutant strain is not implicated in biofilm formation. Our study suggests that the Type VI Secretion System core component VgrG contributes to both virulence and antimicrobial resistance in  A .  baumannii  ATCC 19606.

The role of the type VI secretion system vgrG gene in the virulence and antimicrobial resistance of Acinetobacter baumannii ATCC 19606