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Anxiety disorders (ADs), the most common comorbid illnesses with bipolar disorder (BP) has been reported to associate with dopamine system. Dopamine, metabolized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase 2 (ALDH2), and the distribution of the  ALDH2*1/*1 , and  ALDH2*1/*2+ALDH*2/*2  alleles in the Han Chinese general population is relatively equal. The association between dopamine metabolic enzymes and cognitive performance in patients with bipolar II disorder (BP-II) comorbid with AD is unclear. This study proposed to explore the role of  ALDH2  polymorphisms on neuropsychological performance between BP-II comorbid with or without AD. One hundred ninety-seven BP-II patients with and without a comorbid AD were recruited and compared with 130 healthy controls (HCs). A polymerase chain reaction and a restriction fragment length polymorphism analysis were used to determine genotypes for  ALDH2 , and study participants underwent neuropsychological tests. An interaction between AD comorbidity and the  ALDH2  polymorphisms was found in different domain of cognitive dysfunction in the BP-II patients. The  ALDH2  polymorphisms might have different effects on the neuropsychological performance of BP-II patients with and without comorbid AD.

The aldehyde dehydrogenase 2 polymorphisms on neuropsychological performance in bipolar II disorder with or without comorbid anxiety disorder