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Detecting drug-drug interactions (DDI) is important because information on DDIs can help prevent adverse effects from drug combinations. Since there are many new DDI-related papers published in the biomedical domain, manually extracting DDI information from the literature is a laborious task. However, text mining can be used to find DDIs in the biomedical literature. Among the recently developed neural networks, we use a Recursive Neural Network to improve the performance of DDI extraction. Our recursive neural network model uses a position feature, a subtree containment feature, and an ensemble method to improve the performance of DDI extraction. Compared with the state-of-the-art models, the DDI detection and type classifiers of our model performed 4.4% and 2.8% better, respectively, on the DDIExtraction Challenge’13 test data. We also validated our model on the PK DDI corpus that consists of two types of DDIs data:  in vivo  DDI and  in vitro  DDI. Compared with the existing model, our detection classifier performed 2.3% and 6.7% better on  in vivo  and  in vitro  data respectively. The results of our validation demonstrate that our model can automatically extract DDIs better than existing models.

Drug drug interaction extraction from the literature using a recursive neural network