English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective  There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications.    Methods  133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain  and  CM drugs to those on CM drugs only. Multiple confounders were controlled for.    Results  Those taking opiates  and  CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, ‘very high risk’ waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75–2.17], 1.82 [1.63–2.03], 1.63 [1.45–1.84]), compared to those on CM drugs alone. Those taking neuropathic pain medications  and  CM drugs also demonstrate worse CM profile than those taking CM drugs only.    Conclusions  The impact of medications for chronic pain and sleep upon CM health and obesity is of concern for these classes of drugs which have been recently labelled as dependency forming medications. The results from this cross sectional study warrants further investigation and adds further support to calls for these medications to be prescribed for shorter periods.

The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants