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Background   Pseudomonas aeruginosa  is an opportunistic pathogen with the ability to cause severe nosocomial infections and remains a major problem in burn patients. This organism shows a remarkable antimicrobial resistance and is often resistant to multiple antibiotics. Integron genes as mobile genetic elements are playing an important role in the spread of  P .  aeruginosa  antibiotic resistance. This study was aimed to investigate the occurrence of class 1, and 2 integron genes ( int1 ,  int2) , among  P .  aeruginosa  strains isolated from patients with burn infections.    Methods  In total 93 clinical isolates of  P .  aeruginosa  were screened. The antimicrobial susceptibilities of 9 common antimicrobial agents were tested against the isolates using disk diffusion method. PCR amplification was performed on extracted DNAs for the detection of  int1 , and  int2  genes using the set of specific primers.    Results  The majority of  P .  aeruginosa  isolates were from wound infection (69.9%). In disk diffusion method, most isolates showed remarkable resistance to tested antibiotics with highest against gentamicin (94.62%) and ciprofloxacin (93.55%). PCR amplification revealed that 89(95.7%) of  P .  aeruginosa  strains carried  int1 , but none of them harbored  int2  genes. The distribution of  int1  gene was highest in blood (100%), followed by wound isolates (95.38%).    Conclusions  We demonstrated a high antimicrobial resistance among  P .  aeruginosa  isolates in our setting.  int1  was prevalent and seems to play an important role in multidrug resistance among the isolates. So, performance of antibiotic surveillance programs is necessary for choosing the appropriate therapy and management of infection control practices.

The frequency of class1 and 2 integrons in Pseudomonas aeruginosa strains isolated from burn patients in a burn center of Ahvaz, Iran