English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Galactose and  N -acetyl-D-galactosamine-inhibitable lectin of  Entamoeba histolytica  has roles in pathogenicity and induction of protective immunity in rodent models of amoebiasis. Recently, the intermediate subunit of the lectin, Igl1, of  E .  histolytica  has been shown to have hemolytic activity. However, the corresponding lectin is also expressed in a non-virulent species,  Entamoeba dispar , and another subunit, Igl2, is expressed in the protozoa. Therefore, in this study, we compared the activities of Igl1 and Igl2 subunits from  E .  histolytica  and  E .  dispar  using various regions of recombinant Igl proteins expressed in  Escherichia coli . The recombinant  E .  dispar  Igl proteins had comparable hemolytic activities with those of  E .  histolytica  Igl proteins. Furthermore,  Igl1  gene-silenced  E .  histolytica  trophozoites showed less hemolytic activity compared with vector-transfected trophozoites, indicating that the expression level of Igl1 protein influences the activity. These results suggest that the lower hemolytic activity in  E .  dispar  compared with  E .  histolytica  reflects the lower expression level of Igl1 in the  E .  dispar  parasite.

Comparison of hemolytic activity of the intermediate subunit of Entamoeba histolytica and Entamoeba dispar lectins