English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The imprinting of the mouse  Peg3  domain is controlled through a 4-kb genomic region encompassing the bidirectional promoter and 1 st  exons of  Peg3  and  Usp29 . In the current study, this ICR was inverted to test its orientation dependency for the transcriptional and imprinting control of the  Peg3  domain. The inversion resulted in the exchange of promoters and 1 st  exons between  Peg3  and  Usp29 . Paternal transmission of this inversion caused 10-fold down-regulation of  Peg3  and 2-fold up-regulation of  Usp29  in neonatal heads, consistent with its original promoter strength in each direction. The paternal transmission also resulted in reduced body size among the animals, which was likely contributed by the dramatic down-regulation of  Peg3 . Transmission through either allele caused no changes in the DNA methylation and imprinting status of the  Peg3  domain except that  Zfp264  became bi-allelic through the maternal transmission. Overall, the current study suggests that the orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation, but very critical for the transcriptional regulation of the entire imprinted domain.

Inversion of the imprinting control region of the Peg3 domain