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Marek’s disease (MD), caused by Marek’s disease virus (MDV), remains an economically significant threat to the poultry industry worldwide. Genetic resistance to MD is a promising alternative strategy to augment current control measures (vaccination and management). However, only a few functional genes reportedly conferring MD resistance have been identified. Here, we performed a comparative transcriptomics analysis of two highly inbred yet genetically divergent lines of chickens (line 6 3  and 7 2 ) that are resistant and susceptible to MD, respectively, in response to a very virulent plus strain of MDV (vv+MDV) challenge at cytolytic phase. A total of 203 DEGs in response to MDV challenge were identified in the two lines. Of these, 96 DEGs were in common for both lines, in addition to 36 and 71 DEGs that were specific for line 6 3  and 7 2 , respectively. Functional enrichment analysis results showed the DEGs were significantly enriched in GO terms and pathways associated with immune response. Especially, the four DEGs,  FGA ,  ALB ,  FN1 , and  F13A1  that reportedly facilitate virus invasion or immunosuppression, were found to be significantly up-regulated in the susceptible line 7 2  but down-regulated in the resistant line 6 3  birds. These results provide new resources for future studies to further elucidate the genetic mechanism conferring MD resistance.

Comparative transcriptomics of genetically divergent lines of chickens in response to Marek’s disease virus challenge at cytolytic phase