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Objective  Previous studies demonstrated a role of variations in sterol regulatory element binding protein ( SREBP ) cleavage-activating protein ( SCAP ) in obesity and blood lipids. But the associations between  SCAP  polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in  SCAP  and BP phenotypes in a Chinese pediatric population.    Methods  A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers (rs12487736 and rs12490383) of  SCAP  and BP phenotypes. The associations with continuous and categorical variables were examined by linear regression and logistic regression models under a dominant genetic model for the minor rs12487736 A allele and rs12490383 T allele.    Results  The rs12487736 polymorphism was significantly associated with systolic BP (SBP) (β = 1.66,  P  = 0.003) and diastolic BP (DBP) (β = 1.35,  P  = 0.024) with age, age-squared, sex, study population and body mass index (BMI) adjusted under the dominant genetic model. The rs12490383 polymorphism was significantly associated with SBP (β = 1.71,  P  = 0.004) and SHBP (OR = 1.39, 95%CI: 1.04–1.86,  P  = 0.027). When analyzed by BMI categories, in the normal-weight children, no significant association between the  SCAP  polymorphisms and BP phenotypes was observed (all  P  > 0.05). However, in the overweight/obese children, rs12487736 was significantly associated with SBP (β = 1.6,  P  = 0.019) and SHBP (OR = 1.36, 95%CI: 1.02–1.82;  P  = 0.037), rs12490383 was associated with SBP (β = 2.04,  P  = 0.004) and SHBP (OR = 1.50, 95%CI: 1.10–2.05;  P  = 0.01).    Conclusions  This study demonstrated that  SCAP  rs12487736 and rs12490383 were significantly associated with SBP and SHBP in overweight/obese Chinese children. It provided the evidence for association of  SCAP  with SBP.

plos one

Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children