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Gastric carcinoma is highly prevalent throughout the world. Understanding the pathogenesis of this disease will benefit diagnosis and resolution. Studies show that miRNAs are involved in the tumorigenesis of gastric carcinoma. An initial screening followed by subsequent validation identified that  miR-376c  is up-regulated in gastric carcinoma tissue and the plasma of patients with the disease. In addition, the urinary level of  miR-376c  is also significantly increased in gastric carcinoma patients. The plasma  miR-376c  level was validated as a biomarker for gastric carcinoma, including early stage tumors. The induction of  miR-376c  was found to enrich the proliferation, migration and anchorage-independent growth of carcinoma cells and, furthermore, the repression of the expression of endogenous  miR-376c  was able to reduce such oncogenic phenotypes.  ARID4A  gene is a direct target of  miR-376c . Knockdown of endogenous  ARID4A  increased the oncogenicity of carcinoma cells, while  ARID4A  was found to be drastically down-regulated in tumor tissue. Thus, expression levels of  miR-376c  and  ARID4A  mRNA tended to be opposing in tumor tissue. Our results demonstrate that  miR-376c  functions by suppressing  ARID4A  expression, which in turn enhances the oncogenicity of gastric carcinoma cells. It seems likely that the level of  miR-376c  in plasma and urine could act as invaluable markers for the detection of gastric carcinoma.

miR-376c promotes carcinogenesis and serves as a plasma marker for gastric carcinoma