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The mode of action of  trans -resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by  trans -resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in mice fed with a control diet or a control diet containing  trans -resveratrol were different in cortex, heart and skeletal muscle. In neocortex, we identified 4 up-regulated ( Strap ,  Pkp4 ,  Rab2a ,  Cpne3 ) and 22 down-regulated ( Actn1 ,  Arf3 ,  Atp6v01 ,  Atp1a3 ,  Atp1b2 ,  Cacng7 ,  Crtc1 ,  Dbn1 ,  Dnm1 ,  Epn1 ,  Gfap ,  Hap ,  Mark41 ,  Rab5b ,  Nrxn2 ,  Ogt ,  Palm ,  Ptprn2 ,  Ptprs ,  Syn2 ,  Timp2 ,  Vamp2 ) genes upon  trans -resveratrol consumption. Network analysis of gene products provided evidence of plakophilin 4 up-regulation as a triggering factor for down-regulation of events related to synaptic vesicle transport and neurotransmitter release via underexpression of dynamin1 and Vamp2 (synaptobrevin 2) as node-gene drivers. Analysis by RT-qPCR of some of the selected genes in a glioma cell line showed that dynamin 1 mRNA was down-regulated even in acute  trans -resveratrol treatments. Taken all together, these results give insight on the glial-neuronal networks involved in the neuroprotective role of  trans -resveratrol.

A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression