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Toxoplasma gondii  ( T .  gondii ) microneme protein 8 (MIC8) represents a novel, functional distinct invasion factor. In this study, we generated virus-like particles (VLPs) targeting  Toxoplasma gondii  MIC8 for the first time, and investigated the protection against highly virulent RH strain of  T .  gondii  in a mouse model. We found that VLP vaccination induced  Toxoplasma gondii- specific IgG and IgG1 antibody responses in the sera. Upon challenge infection with RH strain of  T .  gondii  tachyzoites, vaccinated mice showed a significant increase of both IgG antibodies in sera and IgA antibodies in feces compared to those before challenge, and a rapid expansion of both germinal center B cell (B220 + , GL7 + ) and T cell (CD4 + , CD8 + ) populations. Importantly, intranasally immunized mice showed higher neutralizing antibodies and displayed no proinflammatory cytokine IFN-γ in the spleen. Mice were completely protected from a lethal challenge infection with the highly virulent  T .  gondii  (RH) showing no body weight loss (100% survival). Our study shows the effective protection against  T .  gondii  infection provided by VLPs containing microneme protein 8 of  T .  gondii , thus indicating a potential  T .  gondii  vaccine candidate.

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Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection